Structure of PDB 6e4a Chain B

Receptor sequence
>6e4aB (length=125) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPT
3D structure
PDB6e4a Discovery and lead identification of quinazoline-based BRD4 inhibitors.
ChainB
Resolution1.26 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HRY B W81 P82 F83 V87 L92 N140 I146 W40 P41 F42 V46 L51 N99 I105 MOAD: Kd=44nM
BindingDB: Kd=44nM
External links
PDB RCSB:6e4a, PDBe:6e4a, PDBj:6e4a
PDBsum6e4a
PubMed30268702
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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