Structure of PDB 6e3u Chain B

Receptor sequence
>6e3uB (length=292) Species: 10090 (Mus musculus) [Search protein sequence]
SKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLRTHKLLSSVCSMD
NLYLKALEGFIAVVTQDGDMIFLSENISKFMGLTQVELTGHSIFDFTHPC
DHEEIRENLTLSTERDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGQVRV
LSCLIIMCEPIQHPSHMDIPLDSKTFLSRHSMDMKFTYCDDRILELIGYH
PEELLGRSAYEFYHALDSENMTKSHQNLCTKGQVVSGQYRMLAKHGGYVA
LETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTE
3D structure
PDB6e3u Bidirectional modulation of HIF-2 activity through chemical ligands.
ChainB
Resolution2.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HNJ B M252 F254 A277 Y278 Y281 M289 L296 Y307 M309 T321 N341 M184 F186 A209 Y210 Y213 M221 L228 Y239 M241 T253 N273
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0046983 protein dimerization activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6e3u, PDBe:6e3u, PDBj:6e3u
PDBsum6e3u
PubMed30804532
UniProtP97481|EPAS1_MOUSE Endothelial PAS domain-containing protein 1 (Gene Name=Epas1)

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