Structure of PDB 6e3t Chain B

Receptor sequence
>6e3tB (length=281) Species: 10090 (Mus musculus) [Search protein sequence]
ETEVFYELAHELPHSVSSHLDKASIMRLAISFLRTHKLLSSVCDNLYLKA
LEGFIAVVTQDGDMIFLSENISKFMGLTQVELTGHSIFDFTHPCDHEEIR
ENLTLSTERDFFMRMKCTVTNRTVNLKSATWKVLHCTGQVRVLSCLIIMC
EPIQHPSHMDIPLDSKTFLSRHSMDMKFTYCDDRILELIGYHPEELLGRS
AYEFYHALDSENMTKSHQNLCTKGQVVSGQYRMLAKHGGYVWLETQGTVI
YNPRNLQPQCIMCVNYVLSEIEKNDVVFSMD
3D structure
PDB6e3t Bidirectional modulation of HIF-2 activity through chemical ligands.
ChainB
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HO7 B F244 H248 Y281 Y307 M309 L319 T321 C339 N341 F168 H172 Y205 Y231 M233 L243 T245 C263 N265
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0046983 protein dimerization activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6e3t, PDBe:6e3t, PDBj:6e3t
PDBsum6e3t
PubMed30804532
UniProtP97481|EPAS1_MOUSE Endothelial PAS domain-containing protein 1 (Gene Name=Epas1)

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