Structure of PDB 6e3s Chain B

Receptor sequence
>6e3sB (length=290) Species: 10090 (Mus musculus) [Search protein sequence]
SKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLRTHKLLSSVCDNL
YLKALEGFIAVVTQDGDMIFLSENISKFMGLTQVELTGHSIFDFTHPCDH
EEIRENLTLSTERDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGQVRVLS
CLIIMCEPIQHPSHMDIPLDSKTFLSRHSMDMKFTYCDDRILELIGYHPE
ELLGRSAYEFYHALDSENMTKSHQNLCTKGQVVSGQYRMLAKHGGYVALE
TQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTE
3D structure
PDB6e3s Bidirectional modulation of HIF-2 activity through chemical ligands.
ChainB
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 79A B F244 H248 M252 F254 A277 F280 Y281 H293 M309 T321 G323 I337 C339 N341 F174 H178 M182 F184 A207 F210 Y211 H223 M239 T251 G253 I267 C269 N271
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0046983 protein dimerization activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6e3s, PDBe:6e3s, PDBj:6e3s
PDBsum6e3s
PubMed30804532
UniProtP97481|EPAS1_MOUSE Endothelial PAS domain-containing protein 1 (Gene Name=Epas1)

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