Structure of PDB 6e2p Chain B

Receptor sequence
>6e2pB (length=443) Species: 9606 (Homo sapiens) [Search protein sequence]
VYLYHSLEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETER
IWYPPNHVFHHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFV
MSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLA
IYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFKATARNLKL
KYLINLETLQSAFYTEKFEVKEPIFATIIITGNGGIQWSRGKHKESETLT
EQDLQLYCDFPNIIDVSIKSRVVTIHKQDGKNLEIELSSLREALSFVSLI
DGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQ
TGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKK
NFSSLKDLLNCYQMETVRNIIFQFTKCCPPKPKDKSNLLVFRT
3D structure
PDB6e2p Receptor-mediated dimerization of JAK2 FERM domains is required for JAK2 activation.
ChainB
Resolution2.83 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B H172 E176 E177 L179 G180 L184 Y221 H222 R232 N257 H123 E127 E128 L130 G131 L135 Y172 H173 R183 N205
Gene Ontology
Molecular Function
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0042393 histone binding
Biological Process
GO:0006468 protein phosphorylation
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005856 cytoskeleton
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6e2p, PDBe:6e2p, PDBj:6e2p
PDBsum6e2p
PubMed30044226
UniProtO60674|JAK2_HUMAN Tyrosine-protein kinase JAK2 (Gene Name=JAK2)

[Back to BioLiP]