Structure of PDB 6e2n Chain B

Receptor sequence
>6e2nB (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]
LLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPESQPLHE
EIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLK
DNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFG
TSKRLTGTLQYMAPEIIDYGKAADIWSLGCTIIEMATGKPPFYELGEPQA
AMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLK
3D structure
PDB6e2n ASK1 contributes to fibrosis and dysfunction in models of kidney disease.
ChainB
Resolution2.098 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D803 K805 D807 N808 D822 T842
Catalytic site (residue number reindexed from 1) D129 K131 D133 N134 D148 T158
Enzyme Commision number 2.7.11.25: mitogen-activated protein kinase kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KK8 B L686 A707 K709 M754 E755 Q756 V757 G759 G760 D807 L810 D822 L17 A38 K40 M80 E81 Q82 V83 G85 G86 D133 L136 D148 MOAD: ic50=12.5nM
PDBbind-CN: -logKd/Ki=7.90,IC50=12.5nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6e2n, PDBe:6e2n, PDBj:6e2n
PDBsum6e2n
PubMed30024858
UniProtQ99683|M3K5_HUMAN Mitogen-activated protein kinase kinase kinase 5 (Gene Name=MAP3K5)

[Back to BioLiP]