Structure of PDB 6dxl Chain B

Receptor sequence
>6dxlB (length=179) Species: 9606 (Homo sapiens) [Search protein sequence]
FNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILL
PLDCGVPDNLSMADPNIRFLDKLPQQTVYSNSIYELLENGQRAGTCVLEY
ATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRL
IAYQEPSSFSLSQEVLRHLRQEEKEEVTV
3D structure
PDB6dxl Design of amidobenzimidazole STING receptor agonists with systemic activity.
ChainB
Resolution2.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HG4 B S162 Y167 Y240 S241 S10 Y15 Y79 S80 PDBbind-CN: -logKd/Ki=5.80,Kd=1.6uM
BS02 CA B V341 T342 V177 T178
Gene Ontology
Biological Process
GO:0002218 activation of innate immune response
GO:0032481 positive regulation of type I interferon production

View graph for
Biological Process
External links
PDB RCSB:6dxl, PDBe:6dxl, PDBj:6dxl
PDBsum6dxl
PubMed30405246
UniProtQ86WV6|STING_HUMAN Stimulator of interferon genes protein (Gene Name=STING1)

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