Structure of PDB 6dxk Chain B

Receptor sequence
>6dxkB (length=248) Species: 9606 (Homo sapiens) [Search protein sequence]
PTLVSALETIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAK
AIPGFRNLHLDDQMTLLQYSWMYLMAFALGWRSYRQSSANLLCFAPDLII
NEQRMTLPDMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDG
LKSQALFDAIRMTYIKELGKAIVKREGNSSQNSQRFYQLTKLLDSMHEVV
ENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
3D structure
PDB6dxk Discovery of a Potent and Selective Steroidal Glucocorticoid Receptor Antagonist (ORIC-101).
ChainB
Resolution3.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HJ4 B L566 G567 Q570 M604 F623 C736 L37 G38 Q41 M75 F94 C207 BindingDB: IC50=15nM,EC50=>2500nM
External links
PDB RCSB:6dxk, PDBe:6dxk, PDBj:6dxk
PDBsum6dxk
PubMed30091920
UniProtP04150|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

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