Structure of PDB 6dw7 Chain B

Receptor sequence
>6dw7B (length=481) Species: 9606 (Homo sapiens) [Search protein sequence]
DTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASH
NRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCRNLGHGP
FSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPE
EDICFIKEQIVGPLELWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFAR
DCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNS
LHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEA
YTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKI
KREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHV
SFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQY
FVQWCADRNFTKPQDGDVIAPLITPQKKEWN
3D structure
PDB6dw7 The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1.
ChainB
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DTP B V117 N119 V5 N7
BS02 GTP B K116 V117 I118 D137 Q142 R145 K4 V5 I6 D25 Q30 R33
BS03 DTP B R333 R352 K354 N358 K523 R215 R234 K236 N240 K405
BS04 GTP B Y155 V156 V378 R451 Y43 V44 V260 R333
BS05 DTP B V156 F157 R372 H376 K377 V44 F45 R254 H258 K259
External links
PDB RCSB:6dw7, PDBe:6dw7, PDBj:6dw7
PDBsum6dw7
PubMed30305425
UniProtQ9Y3Z3|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

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