Structure of PDB 6dsr Chain B

Receptor sequence
>6dsrB (length=311) Species: 5833 (Plasmodium falciparum) [Search protein sequence]
MGFKVKLEKRRNAINTCLCIGLDPDEKDIENFMKNEKENNYNNIKKNLKE
KYINNVSIKKDILLKAPDKSEEFFYFFNHFCFYIINETNKYALTFKMNFA
FYIPYGSVGIDVLKNVFDYLYELNIPTILDMKINDIGNTVKNYRKFIFEY
LKSDSCTVNIYMGTNMLKDICYDEEKNKYYSAFVLVKTTNPDSAIFQKNL
SLDNKQAYVIMAQEALNMSSYLNLEQNNEFIGFVVGANSYDEMNYIRTYF
PNCYILSPGIGAQNGDLHKTLTNGYHKSYEKILINIGRAITKNPYPQKAA
QMYYDQINAIL
3D structure
PDB6dsr Re-refinement of Plasmodium falciparum orotidine 5'-monophosphate decarboxylase provides a clearer picture of an important malarial drug target.
ChainB
Resolution2.597 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.1.1.23: orotidine-5'-phosphate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 U5P B D141 I142 T145 D135 I136 T139
BS02 U5P B D23 K102 N104 D136 K138 T194 T195 P264 Q269 G293 R294 D23 K96 N98 D130 K132 T188 T189 P258 Q263 G287 R288
Gene Ontology
Molecular Function
GO:0004590 orotidine-5'-phosphate decarboxylase activity
GO:0016831 carboxy-lyase activity
Biological Process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0044205 'de novo' UMP biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6dsr, PDBe:6dsr, PDBj:6dsr
PDBsum6dsr
PubMed30279319
UniProtQ8T6J6

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