Structure of PDB 6drj Chain B

Receptor sequence
>6drjB (length=1266) Species: 7955 (Danio rerio) [Search protein sequence]
CSLASWIKENIKKKECVRETPTDAFGDISFGGLGQKTGKYVRVSSDTSCE
NLYQLMTEQWKLRSPNLLISVTGGAKNFYIKTHLKDKFRRGLIKVAQTTG
AWILTGGTHAGVMKHVGMAVRDYTLSSGSMEGQIVVIGVAPWGVIHNRST
LIHPEGRFPAYYSLDEQGQGRLSCLDINHTHFLLVDDGTQGHYGVEIELR
ARLEKLISKLSLGNRESGVTIPVVCVVLDGGPGTLNTIYNSMLNHTPCVV
LEGSGRLADVIAHVASVPVSKVTMALINRLLKRFFMQEYKNFTELQIIEW
TKKIQDILRMPHLLTVFRIDEDKNYDVDVAILQALLKASRSDEHAGRHCW
ERQLELAVAWNRVDIAESEIFTEESQWTSSDLHPAMFSALVGDKPEFVRL
LLENGVCVREFLEREETLCELYSHLPSCFFLRKLAKRVQGLPGSRKVCLS
HVSEEVRHLLGSFTQPLYIASRYKPADTVWDPGRDLFLWAVVQNNRELAE
IGWEQCRDCIAAALAASKILRKLAQESGEDDSEEATEMLELANHYEKQAI
GVFSECHSWDAQRAQKLLIRISPSWGRSTCLWLALEAHDKSFIAHSGVQA
LLTQIWCGELSVDNPHWKVLLCMIFFPLIYTGFLTFRRDEDIQRQAERTQ
QKLLKPLNCSSRLMSFLKSPQVKFYWNIASYFGFLWLFAVVLMIDFQTSP
SWRELLLYVWLTSLVCEEIRQLYHDFDGSGFRRKAKMYIKDLWNILDVLS
IVLFIAGLICRLQASDTVFYIGKVILCIDFIIFCLRLMAIFSISRTLGPK
IIIVRRMMLDLFFFMFLLSIWVVAYGVAKQGILIENEERLNWIIRGAVYE
PYITIFGNFPTNIDNTLFDISSCSVNASDPLKPKCPMLNADNTPVFPEWL
TIMMLCVYLLFANILLLNLLIAIFNYTFQEVQDNTDTIWKFQRYELIKEY
HSRPALPPPFILLSHLILFIRGVFLRDLPQRHKNFRQELEQTEEEELLSW
EAYMKDNYLASTRQDESQSVEHRIHDTAEKVGAMSELLEREQEMVDEEAP
HMFARQLQYPDSTVRRFPVPEEKVSWEVNFSPYQPPVYNQQALDKHRNPG
GRTGIRGKGALNTLGPNHILHPIFTRWRDAEHKVLEFLAVWEDAEKRWAL
LGGPAQPDEPLAQVLERILGKKLNEKTKTLLKAGEEVYKGYVDDSRNTDN
AWVETSIITLHCDKNTPLMADLNHMVESSLSSHQPLQWREVSSDACRCSY
QREALRQIAHHHNTYF
3D structure
PDB6drj Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium.
ChainB
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 APR B T150 G151 A153 T186 Y271 R278 G309 G311 T312 T72 G73 A75 T108 Y193 R200 G231 G233 T234
BS02 CA B E857 Q860 N883 E718 Q721 N744
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005262 calcium channel activity
GO:0005509 calcium ion binding
GO:0046872 metal ion binding
GO:0047631 ADP-ribose diphosphatase activity
GO:0072570 ADP-D-ribose binding
GO:0072571 mono-ADP-D-ribose binding
GO:0099094 ligand-gated monoatomic cation channel activity
GO:0099604 ligand-gated calcium channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0019722 calcium-mediated signaling
GO:0051289 protein homotetramerization
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6drj, PDBe:6drj, PDBj:6drj
PDBsum6drj
PubMed30250252
UniProtA0A0R4IMY7|TRPM2_DANRE Transient receptor potential cation channel subfamily M member 2 (Gene Name=trpm2)

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