BioLiP

Site
#

Ligand

Ligand
chain

Binding residues on receptor
(original residue number in PDB)

Binding residues on receptor
(residue number reindexed from 1)

Binding affinity

BS01

GLU

Y450 T480 R485 G653 S654 T655 E705

Y441 T471 R476 G631 S632 T633 E683

BS02

CYZ

P494 F495 M496 S497 L759 K763

P485 F486 M487 S488 L737 K741

	Molecular Function
GO:0000149	SNARE binding
GO:0001540	amyloid-beta binding
GO:0004970	glutamate-gated receptor activity
GO:0004971	AMPA glutamate receptor activity
GO:0005230	extracellular ligand-gated monoatomic ion channel activity
GO:0005234	extracellularly glutamate-gated ion channel activity
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0015276	ligand-gated monoatomic ion channel activity
GO:0015277	kainate selective glutamate receptor activity
GO:0019865	immunoglobulin binding
GO:0019901	protein kinase binding
GO:0022849	glutamate-gated calcium ion channel activity
GO:0030165	PDZ domain binding
GO:0035254	glutamate receptor binding
GO:0035255	ionotropic glutamate receptor binding
GO:0038023	signaling receptor activity
GO:0042802	identical protein binding
GO:0044877	protein-containing complex binding
GO:0097110	scaffold protein binding
GO:0099094	ligand-gated monoatomic cation channel activity
GO:0099507	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

	Biological Process
GO:0001919	regulation of receptor recycling
GO:0006816	calcium ion transport
GO:0007268	chemical synaptic transmission
GO:0010226	response to lithium ion
GO:0019722	calcium-mediated signaling
GO:0021987	cerebral cortex development
GO:0031623	receptor internalization
GO:0034220	monoatomic ion transmembrane transport
GO:0035235	ionotropic glutamate receptor signaling pathway
GO:0035249	synaptic transmission, glutamatergic
GO:0045184	establishment of protein localization
GO:0050804	modulation of chemical synaptic transmission
GO:0050806	positive regulation of synaptic transmission
GO:0051262	protein tetramerization
GO:0051966	regulation of synaptic transmission, glutamatergic
GO:0060078	regulation of postsynaptic membrane potential
GO:0060079	excitatory postsynaptic potential
GO:0060992	response to fungicide
GO:0098655	monoatomic cation transmembrane transport
GO:0099505	regulation of presynaptic membrane potential
GO:1905430	cellular response to glycine
GO:1990416	cellular response to brain-derived neurotrophic factor stimulus

Biological Process

GO:0001919

regulation of receptor recycling

GO:0006816

calcium ion transport

GO:0007268

chemical synaptic transmission

GO:0010226

response to lithium ion

GO:0019722

calcium-mediated signaling

GO:0021987

cerebral cortex development

GO:0031623

receptor internalization

GO:0034220

monoatomic ion transmembrane transport

GO:0035235

ionotropic glutamate receptor signaling pathway

GO:0035249

synaptic transmission, glutamatergic

GO:0045184

establishment of protein localization

GO:0050804

modulation of chemical synaptic transmission

GO:0050806

positive regulation of synaptic transmission

GO:0051262

protein tetramerization

GO:0051966

regulation of synaptic transmission, glutamatergic

GO:0060078

regulation of postsynaptic membrane potential

GO:0060079

excitatory postsynaptic potential

GO:0060992

response to fungicide

GO:0098655

monoatomic cation transmembrane transport

GO:0099505

regulation of presynaptic membrane potential

GO:1905430

cellular response to glycine

GO:1990416

cellular response to brain-derived neurotrophic factor stimulus

	Cellular Component
GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0008021	synaptic vesicle
GO:0008328	ionotropic glutamate receptor complex
GO:0009986	cell surface
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0030426	growth cone
GO:0030672	synaptic vesicle membrane
GO:0032279	asymmetric synapse
GO:0032281	AMPA glutamate receptor complex
GO:0032590	dendrite membrane
GO:0032839	dendrite cytoplasm
GO:0032991	protein-containing complex
GO:0036477	somatodendritic compartment
GO:0042734	presynaptic membrane
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043195	terminal bouton
GO:0043197	dendritic spine
GO:0043198	dendritic shaft
GO:0043204	perikaryon
GO:0044326	dendritic spine neck
GO:0044327	dendritic spine head
GO:0045202	synapse
GO:0045211	postsynaptic membrane
GO:0048787	presynaptic active zone membrane
GO:0097060	synaptic membrane
GO:0098685	Schaffer collateral - CA1 synapse
GO:0098793	presynapse
GO:0098839	postsynaptic density membrane
GO:0098978	glutamatergic synapse
GO:0099544	perisynaptic space
GO:0106033	spine synapse

Cellular Component

GO:0005783

endoplasmic reticulum

GO:0005886

plasma membrane

GO:0008021

synaptic vesicle

GO:0008328

ionotropic glutamate receptor complex

GO:0009986

cell surface

GO:0014069