Structure of PDB 6dcl Chain B

Receptor sequence
>6dclB (length=171) Species: 9606 (Homo sapiens) [Search protein sequence]
KEPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGF
GFVTYATVEEVDAAMNARPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKI
FVGGIKEDTEEHHLRDYFEQYGKIEVIEIMTDKRGFAFVTFDDHDSVDKI
VIQKYHTVNGHNCEVRKALSK
3D structure
PDB6dcl Structural basis for terminal loop recognition and stimulation of pri-miRNA-18a processing by hnRNP A1.
ChainB
Resolution2.497 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B K106 F108 G110 G111 M137 K145 R146 F148 F150 E176 R178 L181 K99 F101 G103 G104 M130 K133 R134 F136 F138 E164 R166 L169 PDBbind-CN: Kd=15.5nM
BS02 rna B Q12 K15 F17 G20 M46 R55 G56 F57 F59 E85 K87 A89 V90 R92 S95 H101 Q5 K8 F10 G13 M39 R48 G49 F50 F52 E78 K80 A82 V83 R85 S88 H94 PDBbind-CN: Kd=15.5nM
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding

View graph for
Molecular Function
External links
PDB RCSB:6dcl, PDBe:6dcl, PDBj:6dcl
PDBsum6dcl
PubMed29946118
UniProtP09651|ROA1_HUMAN Heterogeneous nuclear ribonucleoprotein A1 (Gene Name=HNRNPA1)

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