Structure of PDB 6d9r Chain B

Receptor sequence
>6d9rB (length=173) Species: 1392 (Bacillus anthracis) [Search protein sequence]
AMMNQDIEKVLISEEQIQEKVLELGAIIAEDYKNTVPLAIGVLKGAMPFM
ADLLKRTDTYLEMDFMAVSSTGEVKILKDLDTSVEGRDILIVEDIIDSGL
TLSYLVDLFKYRKAKSVKIVTLLDKPTGRKVDLKADYVGFTVPHEFVVGY
GLDYKEQYRNLPYVGVLKPSVYS
3D structure
PDB6d9r Evolution of (p)ppGpp-HPRT regulation through diversification of an allosteric oligomeric interaction.
ChainB
Resolution1.64 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E99 D100 D103 F152 R165
Catalytic site (residue number reindexed from 1) E93 D94 D97 F146 R159
Enzyme Commision number 2.4.2.8: hypoxanthine phosphoribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9DG B D103 F152 V153 L158 D159 D97 F146 V147 L152 D153
BS02 PRP B K43 G44 E99 D100 I101 D103 S104 G105 T107 R165 K44 G45 E93 D94 I95 D97 S98 G99 T101 R159
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004422 hypoxanthine phosphoribosyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0046872 metal ion binding
GO:0052657 guanine phosphoribosyltransferase activity
Biological Process
GO:0006166 purine ribonucleoside salvage
GO:0006178 guanine salvage
GO:0032263 GMP salvage
GO:0032264 IMP salvage
GO:0046100 hypoxanthine metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6d9r, PDBe:6d9r, PDBj:6d9r
PDBsum6d9r
PubMed31552824
UniProtB9ZW32

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