Structure of PDB 6d3x Chain B

Receptor sequence
>6d3xB (length=244) Species: 9606 (Homo sapiens) [Search protein sequence]
FDCGKPQVEPKKCPVVGGCVAHPHSWPWQVSLRTRFGMHFCGGTLISPEW
VLTAAHCLEKSPRPSSYKVILGAHQEVNLEPHVQEIEVSRLFLEPTRKDI
ALLKLSSPAVITDKVIPACLPSPNYVVADRTECFITGWGETQGTFGAGLL
KEAQLPVIENKVCNRYEFLNGRVQSTELCAGHLAGGTDSCQGDSGGPLVC
FEKDKYILQGVTSWGLGCARPNKPGVYVRVSRFVTWIEGVMRNN
3D structure
PDB6d3x Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma.
ChainB
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H603 D646 Q738 G739 D740 S741
Catalytic site (residue number reindexed from 1) H56 D99 Q191 G192 D193 S194
Enzyme Commision number 3.4.21.7: plasmin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B E606 P609 L638 L640 E59 P62 L91 L93
BS02 peptide B M585 F587 H603 D646 R719 D735 S736 C737 Q738 G739 S741 S760 W761 G762 L763 M38 F40 H56 D99 R172 D188 S189 C190 Q191 G192 S194 S213 W214 G215 L216
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6d3x, PDBe:6d3x, PDBj:6d3x
PDBsum6d3x
PubMed30520638
UniProtP00747|PLMN_HUMAN Plasminogen (Gene Name=PLG)

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