Structure of PDB 6cyb Chain B

Receptor sequence
>6cybB (length=347) Species: 9606 (Homo sapiens) [Search protein sequence]
STSLYKKAGFDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAI
LSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCY
LLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALY
SSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATD
LAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTT
RKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMP
IYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFL
3D structure
PDB6cyb Structure-Guided Design and Procognitive Assessment of a Potent and Selective Phosphodiesterase 2A Inhibitor.
ChainB
Resolution1.62 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.17: 3',5'-cyclic-nucleotide phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H660 H696 D697 D808 H91 H127 D128 D239
BS02 FKV B Y655 H656 T768 L770 D808 L809 Q812 I826 Q859 F862 Y86 H87 T199 L201 D239 L240 Q243 I257 Q290 F293 MOAD: ic50=0.96nM
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:6cyb, PDBe:6cyb, PDBj:6cyb
PDBsum6cyb
PubMed30128073
UniProtO00408|PDE2A_HUMAN cGMP-dependent 3',5'-cyclic phosphodiesterase (Gene Name=PDE2A)

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