Structure of PDB 6cvt Chain B

Receptor sequence
>6cvtB (length=177) Species: 9606 (Homo sapiens) [Search protein sequence]
HMGHWSQGLKISMQDPKMQVYKDEQVVVIKDKYPKARYHWLVLPWTSISS
LKAVAREHLELLKHMHTVGEKVIVDFAGSSKLRFRLGYHAIPSMSHVHLH
GISQDFDSPCLKNKKHWNSFNTEYFLESQAVIEMVQEAGRVTVRDGMPEL
LKLPLRCHECQQLLPSIPQLKEHLRKH
3D structure
PDB6cvt Mechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease.
ChainB
Resolution2.941 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.6.1.71: adenosine-5'-diphospho-5'-[DNA] diphosphatase.
3.6.1.72: DNA-3'-diphospho-5'-guanosine diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B W167 Y195 K197 S255 K277 W5 Y33 K35 S93 K115
BS02 dna B K276 S328 I329 P330 K114 S166 I167 P168
BS03 ZN B C319 C322 H335 H339 C157 C160 H173 H177
BS04 AMP B L171 S174 D193 K194 Y195 L203 H251 P254 S255 M256 H260 L9 S12 D31 K32 Y33 L41 H89 P92 S93 M94 H98
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:6cvt, PDBe:6cvt, PDBj:6cvt
PDBsum6cvt
PubMed29934293
UniProtQ7Z2E3|APTX_HUMAN Aprataxin (Gene Name=APTX)

[Back to BioLiP]