Structure of PDB 6cvp Chain B

Receptor sequence
>6cvpB (length=179) Species: 9606 (Homo sapiens) [Search protein sequence]
SHMGHWSQGLKISMQDPKMQVYKDEQVVVIKDKYPKAHYHWLVLPWTSIS
SLKAVAREHLELLKHMHTVGEKVIVDFAGSSKLRFRLGYHAIPSMSHVHL
HVISQDFDSPCLKNKKHWNSFNTEYFLESQAVIEMVQEAGRVTVRDGMPE
LLKLPLRCHECQQLLPSIPQLKEHLRKHW
3D structure
PDB6cvp Mechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease.
ChainB
Resolution1.999 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.71: adenosine-5'-diphospho-5'-[DNA] diphosphatase.
3.6.1.72: DNA-3'-diphospho-5'-guanosine diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B W167 Y195 K197 S255 K277 H278 W6 Y34 K36 S94 K116 H117
BS02 dna B S328 I329 P330 S167 I168 P169
BS03 AMP B L171 D193 K194 Y195 L203 H251 P254 S255 M256 H260 H262 L10 D32 K33 Y34 L42 H90 P93 S94 M95 H99 H101
BS04 ZN B C319 C322 H335 H339 C158 C161 H174 H178
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:6cvp, PDBe:6cvp, PDBj:6cvp
PDBsum6cvp
PubMed29934293
UniProtQ7Z2E3|APTX_HUMAN Aprataxin (Gene Name=APTX)

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