Structure of PDB 6cvo Chain B

Receptor sequence
>6cvoB (length=178) Species: 9606 (Homo sapiens) [Search protein sequence]
HMGHWSQGLKISMQDPKMQVYKDEQVVVIKDKYPKARYHWLVLPWTSISS
LKAVAREHLELLKHMHTVGEKVIVDFAGSSKLRFRLGYHAIPSMSHVHLH
VISQDFDSPCLKNKKHWNSFNTEYFLESQAVIEMVQEAGRVTVRDGMPEL
LKLPLRCHECQQLLPSIPQLKEHLRKHW
3D structure
PDB6cvo Mechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease.
ChainB
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.71: adenosine-5'-diphospho-5'-[DNA] diphosphatase.
3.6.1.72: DNA-3'-diphospho-5'-guanosine diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B K276 S328 I329 K114 S166 I167
BS02 dna B W167 Y195 K197 S255 K277 H278 W5 Y33 K35 S93 K115 H116
BS03 AMP B L171 D193 K194 Y195 L203 H251 P254 S255 M256 H260 H262 L9 D31 K32 Y33 L41 H89 P92 S93 M94 H98 H100
BS04 ZN B C319 C322 H335 H339 C157 C160 H173 H177
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:6cvo, PDBe:6cvo, PDBj:6cvo
PDBsum6cvo
PubMed29934293
UniProtQ7Z2E3|APTX_HUMAN Aprataxin (Gene Name=APTX)

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