Structure of PDB 6csc Chain B

Receptor sequence

>6cscB (length=434) Species: 9031 (Gallus gallus)

TNLKDVLASLIPKEQARIKTFRQQHGNTAVGQITVDMSYGGMRGMKGLIY
ETSVLDPDEGIRFRGFSIPECQKLLPKAGGGEEPLPEGLFWLLVTGQIPT
PEQVSWVSKEWAKRAALPSHVVTMLDNFPTNLHPMSQLSAAITALNSESN
FARAYAEGINRTKYWEFVYEDAMDLIAKLPCVAAKIYRNLYRAGSSIGAI
DSKLDWSHNFTNMLGYTDPQFTELMRLYLTIHSDHEGGNVSAHTSHLVGS
ALSDPYLSFAAAMNGLAGPLHGLANQEVLLWLSQLQKDLGADASDEKLRD
YIWNTLNSGRVVPGYGHAVLRKTDPRYTCQREFALKHLPSDPMFKLVAQL
YKIVPNVLLEQGKAKNPWPNVDAHSGVLLQYYGMTEMNYYTVLFGVSRAL
GVLAQLIWSRALGFPLERPKSMSTAGLEKLSAGG

3D structure

• PDB: 6csc Crystallographic Refinement and Atomic Models of Two Different Forms of Citrate Synthase at 2.7 And 1.7 A Resolution
• Chain: B
• Resolution: 2.25 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): S244 H274 H320 R329 D375
• Catalytic site (residue number reindexed from 1): S241 H271 H317 R326 D372
• Enzyme Commision number: 2.3.3.1: citrate (Si)-synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	COF	B	R164 L419	R161 L416
BS02	COF	B	R46 L273 A277 V314 V315 P316 G317 Y318 G319 H320 A321 K366 A367 K368 N373	R43 L270 A274 V311 V312 P313 G314 Y315 G316 H317 A318 K363 A364 K365 N370

Gene Ontology

Molecular Function

• GO:0004108 citrate (Si)-synthase activity
• GO:0046912 acyltransferase activity, acyl groups converted into alkyl on transfer

Biological Process

• GO:0006099 tricarboxylic acid cycle
• GO:0006101 citrate metabolic process

External links

• PDB: RCSB:6csc, PDBe:6csc, PDBj:6csc
• PDBsum: 6csc
• UniProt: P23007|CISY_CHICK Citrate synthase, mitochondrial (Gene Name=CS)