Structure of PDB 6cqd Chain B

Receptor sequence
>6cqdB (length=291) Species: 9606 (Homo sapiens) [Search protein sequence]
VDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPD
DDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIY
QVTGSLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRL
ADFGISAQIGAELARRLEFIGTPYWMAPEVAAVALKGGYNELCDIWSLGI
TAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKV
TLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNG
3D structure
PDB6cqd Hematopoietic Progenitor Kinase-1 Structure in a Domain-Swapped Dimer.
ChainB
Resolution2.12 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D137 K139 A141 N142 D155 A164 T175
Catalytic site (residue number reindexed from 1) D134 K136 A138 N139 D152 A161 T172
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B N142 D155 N139 D152
BS02 ANP B L23 G25 G26 V31 A44 K46 M91 E92 C94 D101 L144 D155 L20 G22 G23 V28 A41 K43 M88 E89 C91 D98 L141 D152
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6cqd, PDBe:6cqd, PDBj:6cqd
PDBsum6cqd
PubMed30503777
UniProtQ92918|M4K1_HUMAN Mitogen-activated protein kinase kinase kinase kinase 1 (Gene Name=MAP4K1)

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