Structure of PDB 6cq8 Chain B

Receptor sequence

>6cq8B (length=282) Species: 10090 (Mus musculus)

SDSAINVMKWKTVSTIFLVVVLYLIIGATVFKALEQPQEISQRTTIVIQR
EKFLRAHPCVSDQELDELIQQIVAAINAGIIPLGASSNQVSHWDLGSSFF
FAGTVITTIGFGNISPRTEGGKIFCIIYALLGIPLFGFLLAGVGDQLGTI
FGKGIAKVEDTFIKWNVSQTKIRIISTIIFILFGCVLFVALPAVIFKHIE
GWSALDAIYFVVITLTTIGFGDYVAGGSDIEYLDFYKPVVWFWILVGLAY
FAAVLSMIGDWLRVIAKKTKEAVGEFRAHAAE

3D structure

• PDB: 6cq8 K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site.
• Chain: B
• Resolution: 3.0 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	K	B	G144 F145 G146 G253 F254	G110 F111 G112 G219 F220
BS02	K	B	T142 I143 G144 T251 I252	T108 I109 G110 T217 I218
BS03	K	B	I143 G144 F145 I252 G253 F254	I109 G110 F111 I218 G219 F220
BS04	K	B	T142 T251	T108 T217
BS05	Q6F	B	S131 F134 G137 A259 G260 G261 K271 V274 W275 I278	S97 F100 G103 A225 G226 G227 K237 V240 W241 I244

Gene Ontology

Molecular Function

• GO:0005267 potassium channel activity

Biological Process

• GO:0071805 potassium ion transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:6cq8, PDBe:6cq8, PDBj:6cq8
• PDBsum: 6cq8
• PubMed: 28693035
• UniProt: P97438|KCNK2_MOUSE Potassium channel subfamily K member 2 (Gene Name=Kcnk2)