Structure of PDB 6coj Chain B

Receptor sequence
>6cojB (length=248) Species: 101510 (Rhodococcus jostii RHA1) [Search protein sequence]
TEVTRAEYCAIACADIFSGAGEIMASPMATLPLIGARLARLTTEPDLLIT
DGEALIFADTPAVGAKAPIEGWMPFRKVFDVVASGRRHVVMGANQIDRHG
NQNLSAFGPLQQPTRQMFGVRGAPGNTINHPTSYWVGKHTSRVFCDTVDI
VSGVGYDQIDPENPAYRFHHLHRVVSNLGVFDFGGPDHTFRALSLHPGVT
ADQVADNTSFEVAGLADAGVTREPTDEELRLIREVLDPRSLRDREVSV
3D structure
PDB6coj IpdAB, a virulence factor inMycobacterium tuberculosis, is a cholesterol ring-cleaving hydrolase.
ChainB
Resolution1.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.1.99.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 F8G B M33 F84 R92 M96 G97 A98 N99 L109 F112 T119 R120 R126 N131 R147 M28 F79 R87 M91 G92 A93 N94 L104 F107 T114 R115 R121 N126 R142 PDBbind-CN: -logKd/Ki=6.40,Kd=0.4uM
Gene Ontology
Biological Process
GO:0006707 cholesterol catabolic process
GO:0008203 cholesterol metabolic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6coj, PDBe:6coj, PDBj:6coj
PDBsum6coj
PubMed29581275
UniProtQ0S7Q0|IPDB_RHOJR Cholesterol ring-cleaving hydrolase IpdB subunit (Gene Name=ipdB)

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