Structure of PDB 6cm2 Chain B

Receptor sequence

>6cm2B (length=481) Species: 9606 (Homo sapiens) [Search protein sequence]

DTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASH
NRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCRNLGHGP
FSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPE
EDICFIKEQIVGPLELWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFAR
DCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNS
LHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEA
YTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKI
KREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHV
SFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQY
FVQWCADRNFTKPQDGDVIAPLITPQKKEWN

3D structure

PDB

6cm2 Selective inactivation of hypomethylating agents by SAMHD1 provides a rationale for therapeutic stratification in AML.

Chain

Resolution

2.14 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	F6G	B	V156 F157 R372 H376 K377	V44 F45 R254 H258 K259
BS02	F6G	B	R333 R352 K354 K523	R215 R234 K236 K405
BS03	GTP	B	K116 V117 I118 D137 Q142 R145	K4 V5 I6 D25 Q30 R33
BS04	F6G	B	L150 R164 H215 H233 K312 Y315 D319 R366 H370 Y374	L38 R52 H103 H121 K194 Y197 D201 R248 H252 Y256
BS05	GTP	B	Y155 V156 V378 R451 K455	Y43 V44 V260 R333 K337

External links

PDB	RCSB:6cm2, PDBe:6cm2, PDBj:6cm2
PDBsum	6cm2
PubMed	31375673
UniProt	Q9Y3Z3\|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

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