Structure of PDB 6cid Chain B

Receptor sequence
>6cidB (length=419) Species: 9606 (Homo sapiens) [Search protein sequence]
RFLKVKNWETEVVLTDTLHLKSTLETGCTEYICMGSIMHPSQHARRPEDV
ATKDQLFPLAKEFIDQYYSSIKRFGSKAHMERLEEVNKEIDTTSTYQLKD
TELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVKY
ATNKGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPAN
VQFTEICIQQGWKPPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRH
PKFEWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVRDY
CDNSRYNILEEVAKKMNLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTI
VDHHSATESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNY
RLTPSFEYQPDPWNTHVWK
3D structure
PDB6cid Structural Basis for Isoform Selective Nitric Oxide Synthase Inhibition by Thiophene-2-carboximidamides.
ChainB
Resolution1.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C420 R423 W592 E597
Catalytic site (residue number reindexed from 1) C117 R120 W289 E294
Enzyme Commision number 1.14.13.39: nitric-oxide synthase (NADPH).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 H4B B F696 H697 E699 F393 H394 E396
BS02 ZN B C331 C336 C28 C33
BS03 HEM B H346 W414 R419 C420 F589 W592 E597 W683 F709 Y711 H43 W111 R116 C117 F286 W289 E294 W380 F406 Y408
BS04 H4B B S339 M341 R601 V682 W683 S36 M38 R298 V379 W380
BS05 F2J B P570 V572 F589 S590 G591 E597 P267 V269 F286 S287 G288 E294
Gene Ontology
Molecular Function
GO:0004517 nitric-oxide synthase activity
Biological Process
GO:0006809 nitric oxide biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6cid, PDBe:6cid, PDBj:6cid
PDBsum6cid
PubMed30335983
UniProtP29475|NOS1_HUMAN Nitric oxide synthase 1 (Gene Name=NOS1)

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