Structure of PDB 6cad Chain B

Receptor sequence
>6cadB (length=248) Species: 9606 (Homo sapiens) [Search protein sequence]
DWEIPDGQITVGQRIGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKN
EVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHASTKFEMK
KLIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFSGSILW
MAPEVIRMPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGS
LSPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELAREL
3D structure
PDB6cad Effects of rigidity on the selectivity of protein kinase inhibitors.
ChainB
Resolution2.55 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D576 K578 N580 N581 D594 S616
Catalytic site (residue number reindexed from 1) D125 K127 N129 N130 D143 S147
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EU4 B A481 K483 L514 I527 T529 W531 C532 I592 G593 D594 A31 K33 L64 I77 T79 W81 C82 I141 G142 D143 BindingDB: IC50=>10000nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6cad, PDBe:6cad, PDBj:6cad
PDBsum6cad
PubMed29407977
UniProtP15056|BRAF_HUMAN Serine/threonine-protein kinase B-raf (Gene Name=BRAF)

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