Structure of PDB 6ca4 Chain B

Receptor sequence
>6ca4B (length=244) Species: 7955 (Danio rerio) [Search protein sequence]
SSKLSIISWNVDGLDTNNLSDRARGLCSYLALYTPDVVFLQELIPAYVQY
LKKRAVSYLFFEGSDDGYFTGIMLRKSRVKFLESEIICFPTTQMMRNLLI
AQVTFSGQKLYLMTSHLESTRNQSQERTKQLRVVLQKIKEAPEDAIVIFA
GDTNLRDAEVANVGGLPAGVCDVWEQLGKQEHCRYTWDTQANAACKLRFD
RIFLRSAKTAPPVTPDHMALIGMEKLDCGRYTSDHWGIYCTFNT
3D structure
PDB6ca4 New fluorescence-based high-throughput screening assay for small molecule inhibitors of tyrosyl-DNA phosphodiesterase 2 (TDP2).
ChainB
Resolution1.623 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B D131 E161 D12 E42
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:6ca4, PDBe:6ca4, PDBj:6ca4
PDBsum6ca4
PubMed29574079
UniProtQ5XJA0|TYDP2_DANRE Tyrosyl-DNA phosphodiesterase 2 (Gene Name=tdp2)

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