Structure of PDB 6c91 Chain B

Receptor sequence
>6c91B (length=216) Species: 9615 (Canis lupus familiaris) [Search protein sequence]
REKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLIS
LTDENALAGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKS
GTSEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNE
FSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPI
YVWSSKTTVWDWELMN
3D structure
PDB6c91 Structure Based Design of a Grp94-Selective Inhibitor: Exploiting a Key Residue in Grp94 To Optimize Paralog-Selective Binding.
ChainB
Resolution2.895 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EQD B D149 M154 N162 F195 W223 T245 I247 D80 M85 N93 F116 W144 T166 I168 BindingDB: Ki=440nM,IC50=1200nM
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0051082 unfolded protein binding
GO:0140662 ATP-dependent protein folding chaperone
Biological Process
GO:0006457 protein folding

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Molecular Function
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Biological Process
External links
PDB RCSB:6c91, PDBe:6c91, PDBj:6c91
PDBsum6c91
PubMed29528635
UniProtP41148|ENPL_CANLF Endoplasmin (Gene Name=HSP90B1)

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