Structure of PDB 6c7f Chain B

Receptor sequence
>6c7fB (length=336) Species: 9606 (Homo sapiens) [Search protein sequence]
YTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINN
YKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYL
EDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHF
AQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQ
KMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFF
SQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKA
AELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLD
3D structure
PDB6c7f Mathematical and Structural Characterization of Strong Nonadditive Structure-Activity Relationship Caused by Protein Conformational Changes.
ChainB
Resolution1.82 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.17: 3',5'-cyclic-nucleotide phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EOS B T768 L770 I826 F830 M847 Q859 F862 T187 L189 I245 F249 M266 Q278 F281 MOAD: ic50=0.00000001M
BS02 ZN B H660 H696 D697 D808 H79 H115 D116 D227
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:6c7f, PDBe:6c7f, PDBj:6c7f
PDBsum6c7f
PubMed30070482
UniProtO00408|PDE2A_HUMAN cGMP-dependent 3',5'-cyclic phosphodiesterase (Gene Name=PDE2A)

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