Structure of PDB 6c6p Chain B

Receptor sequence

>6c6pB (length=449) Species: 9606 (Homo sapiens)

DPEVIIVGAGVLGSALAAVLSRDGRKVTVIERDLKEPDRIVGEFLQPGGY
HVLKDLGLGDTVEGLDAQVVNGYMIHDQESKSEVQIPYPLSENNQVQSGR
AFHHGRFIMSLRKAAMAEPNAKFIEGVVLQLLEEDDVVMGVQYKDKETGD
IKELHAPLTVVADGLFSKFRKSLVSNKVSVSSHFVGFLMKNAPQFKANHA
ELILANPSPVLIYQISSSETRVLVDIRGEMPRNLREYMVEKIYPQIPDHL
KEPFLEATDNSHLRSMPASFLPPSSVKKRGVLLLGDAYNMRHPLTGGGMT
VAFKDIKLWRKLLKGIPDLYDDAAIFEAKKSFYWARKTSHSFVVNILAQA
LYELFSATDDSLHQLRKACFLYFKLGGECVAGPVGLLSVLSPNPLVLIGH
FFAVAIYAVYFCFKSEPWITKPRALLSSGAVLYKACSVIFPLIYSEMKY

3D structure

• PDB: 6c6p Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase.
• Chain: B
• Resolution: 2.5 Å

Enzymatic activity

• Enzyme Commision number: 1.14.14.17: squalene monooxygenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	EMV	B	F166 Y195 L324 L333 Y335 P415 L416 G418 L469 L473 F477 F495 P505 V506 L509	F44 Y73 L202 L211 Y213 P293 L294 G296 L347 L351 F355 F373 P383 V384 L387	BindingDB: IC50=20nM
BS02	FAD	B	G130 G132 V133 L134 E153 R154 V163 G164 F166 V250 D285 G286 D408 P415 G418 G420 M421	G8 G10 V11 L12 E31 R32 V41 G42 F44 V128 D163 G164 D286 P293 G296 G298 M299

Gene Ontology

Molecular Function

• GO:0004506 squalene monooxygenase activity
• GO:0050660 flavin adenine dinucleotide binding

Biological Process

• GO:0016126 sterol biosynthetic process

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:6c6p, PDBe:6c6p, PDBj:6c6p
• PDBsum: 6c6p
• PubMed: 30626872
• UniProt: Q14534|ERG1_HUMAN Squalene monooxygenase (Gene Name=SQLE)