Structure of PDB 6c67 Chain B

Receptor sequence
>6c67B (length=314) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
TIAVTGSIATDHLMRFPGRFSEQLVSLSFLVDDLVMHRGGVAGNMAFAIG
VLGGEVALVGAAGADFADYRDWLKARGVNCDHVLISETAHTARFTCTTDV
DMAQIASFYPGAMSEARNIKLADVVSAIGKPELVIIGANDPEAMFLHTEE
CRKLGLAFAADPSQQLARLSGEEIRRLVNGAAYLFTNDYEWDLLLSKTGW
SEADVMAQIDLRVTTLGPKGVDLVEPDGTTIHVGVVPETSQTDPTGVGDA
FRAGFLTGRSAGLGLERSAQLGSLVAVLVLESTGTQEWQWDYEAAASRLA
GAYGEHAAAEIVAV
3D structure
PDB6c67 Structure-Guided Drug Design of 6-Substituted Adenosine Analogues as Potent Inhibitors of Mycobacterium tuberculosis Adenosine Kinase.
ChainB
Resolution2.11 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.20: adenosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5ID B S8 D12 G47 G48 N52 F102 F116 Q172 Q173 G254 D257 S7 D11 G39 G40 N44 F94 F108 Q164 Q165 G246 D249 BindingDB: Ki=210nM,IC50=1200nM
BS02 5ID B M110 G225 P226 V243 E246 A284 V285 L288 M102 G217 P218 V235 E238 A276 V277 L280 BindingDB: Ki=210nM,IC50=1200nM
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004001 adenosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0032567 dGTP binding
Biological Process
GO:0006166 purine ribonucleoside salvage
GO:0016310 phosphorylation
GO:0044209 AMP salvage
Cellular Component
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6c67, PDBe:6c67, PDBj:6c67
PDBsum6c67
PubMed31002508
UniProtP9WID5|ADOK_MYCTU Adenosine kinase (Gene Name=adoK)

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