Structure of PDB 6c5u Chain B

Receptor sequence
>6c5uB (length=292) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
NATNVKAMKYLIEHYFDNFKVDSIEIIGSGYDSVAYLVNNEYIFKTKFSG
YAKEKAIYNFLNTNLETNVKIPNIEYSYISDELSILGYKEIKGTFLTPEI
YSTMSEEEQNLLKRDIASFLRQMHGLDYTDISECTIDNKQNVLEEYILLR
ETIYNDLTDIEKDYIESFMERLNATTVFEGKKCLCHNDFSCNHLLLDGNN
RLTGIIDFGDSGIIDEYCDFIYLLEDSEEEIGTNFGEDILRMYGNIDIEK
AKEYQDIVEEYYPIETIVYGIKNIKQEFIENGRKEIYKRTYK
3D structure
PDB6c5u Plasticity of Aminoglycoside Binding to Antibiotic Kinase APH(2′′)-Ia.
ChainB
Resolution2.41 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.7.1.190: aminoglycoside 2''-phosphotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP B S214 I224 K226 Y237 Y274 E276 I277 F281 I392 D393 S33 I43 K45 Y51 Y88 E90 I91 F95 I206 D207
BS02 RIO B D374 Y408 E411 E415 E445 Y448 D188 Y222 E225 E229 E259 Y262
BS03 MG B H379 D393 H193 D207
External links
PDB RCSB:6c5u, PDBe:6c5u, PDBj:6c5u
PDBsum6c5u
PubMed29661878
UniProtP0A0C1|AACA_STAAU Bifunctional AAC/APH (Gene Name=aacA-aphD)

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