Structure of PDB 6c4d Chain B

Receptor sequence
>6c4dB (length=266) Species: 9606 (Homo sapiens) [Search protein sequence]
LNVIKMKSSDFLESAELKVSLAFHRTQGLMIMKTVYKGPNCIEHNEALLE
EAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPL
SVKGRIILEIIEGMAYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASF
KMWSKLNNEGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPY
ENAIAEQQLIMAIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTF
PGIEEKFRPFYLSQLE
3D structure
PDB6c4d Discovery of 7-Oxo-2,4,5,7-tetrahydro-6 H-pyrazolo[3,4- c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure-Kinetic Relationships.
ChainB
Resolution2.52 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D138 K140 E142 N143 D156 T189
Catalytic site (residue number reindexed from 1) D126 K128 E130 N131 D144 T161
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EJP B V31 K45 M67 V76 L90 M92 A155 D156 L157 V19 K33 M55 V64 L78 M80 A143 D144 L145 BindingDB: IC50=1.3nM,Ki=0.912011nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6c4d, PDBe:6c4d, PDBj:6c4d
PDBsum6c4d
PubMed29485864
UniProtQ13546|RIPK1_HUMAN Receptor-interacting serine/threonine-protein kinase 1 (Gene Name=RIPK1)

[Back to BioLiP]