Structure of PDB 6c1i Chain B

Receptor sequence
>6c1iB (length=258) Species: 9606 (Homo sapiens) [Search protein sequence]
ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLM
MGEDKIKFKHSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLND
QVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDF
MEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNL
LQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTEHPL
LQEIYKDL
3D structure
PDB6c1i A structural mechanism for directing corepressor-selective inverse agonism of PPAR gamma.
ChainB
Resolution2.26 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EEY B F282 C285 R288 S289 H323 F363 H449 L453 F69 C72 R75 S76 H110 F150 H236 L240 MOAD: ic50=85nM
BindingDB: IC50=1000nM
BS02 KNA B C285 M364 C72 M151
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6c1i, PDBe:6c1i, PDBj:6c1i
PDBsum6c1i
PubMed30409975
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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