Structure of PDB 6c18 Chain B

Receptor sequence
>6c18B (length=255) Species: 9606 (Homo sapiens) [Search protein sequence]
PEDPRWELPRDRLVLGKPLGGQVVLAEAIGLDKPNRVTKVAVKMLKSDAT
EKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLRE
YLQARRQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVM
KIADFPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVE
ELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI
VALTS
3D structure
PDB6c18 Understanding the structural requirements for covalent inhibition of FGFR1-3
ChainB
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D623 A625 R627 N628 D641
Catalytic site (residue number reindexed from 1) D136 A138 R140 N141 D154
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YY5 B V492 A512 K514 V561 Y563 A564 G567 E571 L630 A640 D641 V23 A41 K43 V90 Y92 A93 G96 E100 L143 A153 D154
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005007 fibroblast growth factor receptor activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6c18, PDBe:6c18, PDBj:6c18
PDBsum6c18
PubMed
UniProtP11362|FGFR1_HUMAN Fibroblast growth factor receptor 1 (Gene Name=FGFR1)

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