Structure of PDB 6c12 Chain B

Receptor sequence
>6c12B (length=537) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
MKLPVREFDAVVIGAGGAGMRAALQISQSGQTCALLSKVFPTRSHTVSAQ
GGNWEWHMYDTVKGSDYIGDQDAIEYMCKTGPEAILELEHMADRTGHALL
HTLYQQNLKNHTTIFSEWYALDLVKNQDGAVVGCTALCIETGEVVYFKAR
ATVLATGGAGRIYQSTTNAHINTGDGVGMAIRAGVPVQDMEMWQFHPTGI
AGAGVLVTEGCRGEGGYLLNKHGERFMERYAPNAKDLAGRDVVARSIMIE
IREGRGCDGPWGPHAKLKLDHLGKEVLESRLPGILELSRTFAHVDPVKEP
IPVIPTCHYMMGGIPTKVTGQALTVNEKGEDVVVPGLFAVGEIACVSVHG
ANRLGGNSLLDLVVFGRAAGLHLQESIAEQGALRDASESDVEASLDRLNR
WNNNRNGEDPVAIRKALQECMQHNFSVFREGDAMAKGLEQLKVIRERLKN
ARLDDTSSEFNTQRVECLELDNLMETAYATAVSANFRTESRGAHSRFDFP
DRDDENWLCHSLYLPESESMTRRSVNMEPKLRPAFPP
3D structure
PDB6c12 Crystal structure of bacterial succinate:quinone oxidoreductase flavoprotein SdhA in complex with its assembly factor SdhE.
ChainB
Resolution2.15 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) Q240 H242 L252 E255 R258 R286 H354 Y355 R399
Catalytic site (residue number reindexed from 1) Q194 H196 L206 E209 R212 R240 H308 Y309 R353
Enzyme Commision number 1.3.5.1: succinate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD B G14 A15 G16 A18 S37 K38 V39 S44 H45 T46 S48 A49 Q50 Y165 A166 A201 T202 G203 D221 H354 Y355 E388 G402 S404 L405 L408 G14 A15 G16 A18 S37 K38 V39 S44 H45 T46 S48 A49 Q50 Y119 A120 A155 T156 G157 D175 H308 Y309 E342 G356 S358 L359 L362
Gene Ontology
Molecular Function
GO:0000104 succinate dehydrogenase activity
GO:0005515 protein binding
GO:0008177 succinate dehydrogenase (quinone) activity
GO:0009055 electron transfer activity
GO:0016491 oxidoreductase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0006099 tricarboxylic acid cycle
GO:0009060 aerobic respiration
GO:0009061 anaerobic respiration
GO:0019646 aerobic electron transport chain
GO:0022900 electron transport chain
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0045273 respiratory chain complex II (succinate dehydrogenase)

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6c12, PDBe:6c12, PDBj:6c12
PDBsum6c12
PubMed29514959
UniProtP0AC41|SDHA_ECOLI Succinate dehydrogenase flavoprotein subunit (Gene Name=sdhA)

[Back to BioLiP]