Structure of PDB 6c0m Chain B

Receptor sequence
>6c0mB (length=428) Species: 11216 (Human respirovirus 3) [Search protein sequence]
ITHDVGIKPLNPDDFWRCTSGLPSLMKTPKIRLMPGPGLLAMPTTVDGCV
RTPSLVINDLIYAYTSNLITRGCQDIGKSYQVLQIGIITVNSDLVPDLNP
RISHTFNINDNRKSCSLALLNTDVYQLCSTPKVDERSDYASSGIEDIVLD
IVNHDGSISTTRFKNNNISFDQPYAALYPSVGPGIYYKGKIIFLGYGGLE
HPINENAICNTTGCPGKTQRDCNQASHSPWFSDRRMVNSIIVVDKSIPKL
KVWTISMRQNYWGSEGRLLLLGNKIYIYTRSTSWHSKLQLGIIDITDYSD
IRIKWTWHNVLSRPGNNECPWGHSCPDGCITGVYTDAYPLNPTGSIVSSV
ILDSQKSRVNPVITYSTATERVNELAIRNKTLSAGYTTTSCITHYNKGYC
FHIVEINHKSLDTFQPMLFKTEIPKSCS
3D structure
PDB6c0m Structural Insights into Human Parainfluenza Virus 3 Hemagglutinin-Neuraminidase Using Unsaturated 3- N-Substituted Sialic Acids as Probes.
ChainB
Resolution1.83 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8LM B I243 S244 H245 T246 I102 S103 H104 T105 MOAD: ic50=31.8uM
BS02 CA B D279 S282 S283 G284 A316 D138 S141 S142 G143 A175
BS03 8LM B C190 R192 T193 C214 E276 Y319 Y337 E409 R424 R502 F558 C49 R51 T52 C73 E135 Y178 Y196 E265 R280 R358 F414 MOAD: ic50=31.8uM
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity
GO:0046789 host cell surface receptor binding
Biological Process
GO:0019058 viral life cycle
Cellular Component
GO:0019031 viral envelope

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6c0m, PDBe:6c0m, PDBj:6c0m
PDBsum6c0m
PubMed29693380
UniProtG8G134

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