Structure of PDB 6c0e Chain B

Receptor sequence
>6c0eB (length=414) Species: 272624 (Legionella pneumophila subsp. pneumophila str. Philadelphia 1) [Search protein sequence]
MTYDKIKVPAQGEAITVSLHVPDNPIIPFIEGDGIGVDVTPPMIRVVDAA
VQKAYGNKRKISWMEVYAGEKATKVYGGDQWLPKETLDAMKKYVVSIKGP
LTTPVGGGIRSLNVAIRQDMDLYVCLRPIRYFNGVPSPVREPWKTDMVIF
RENSEDIYAGIEWQADTPEAKKVIQFLTKEMGVKKIRFPEHCGIGVKPVS
REGTTRLVKAAIQYAIDNDRSTVTLVHKGNIMKFTEGAFKDWGYQVARDS
FGAKEYQGGPWMEFKNPKTGKQIIINDVIADAFLQQILLRPEDYSVIATL
NLNGDYISDALAAQVGGIGIAPGANISDQMAVFEATHGTAPKYAGQNKVN
PGSIILSAEMMLRHMGWYEAADLIIRGMEGAIEAKTVTYDFERGMQGATL
VSSSGFADAMIKHM
3D structure
PDB6c0e Crystal Structure of Isocitrate Dehydrogenase from Legionella pneumophila with bound NADPH with an ??-ketoglutarate adduct
ChainB
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y166 K236 D289 D313
Catalytic site (residue number reindexed from 1) Y158 K228 D281 D305
Enzyme Commision number 1.1.1.42: isocitrate dehydrogenase (NADP(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EE1 B N238 I287 R298 N230 I279 R290
BS02 EE1 B P108 L109 T111 S119 N121 R125 R135 R159 D313 I326 E342 H345 G346 T347 A348 K350 Y351 V357 N358 Y397 D398 P100 L101 T103 S111 N113 R117 R127 R151 D305 I318 E334 H337 G338 T339 A340 K342 Y343 V349 N350 Y389 D390
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004450 isocitrate dehydrogenase (NADP+) activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0046872 metal ion binding
GO:0051287 NAD binding
Biological Process
GO:0006097 glyoxylate cycle
GO:0006099 tricarboxylic acid cycle

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Molecular Function
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Biological Process
External links
PDB RCSB:6c0e, PDBe:6c0e, PDBj:6c0e
PDBsum6c0e
PubMed
UniProtQ5ZXB6

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