Structure of PDB 6c07 Chain B

Receptor sequence
>6c07B (length=368) Species: 353152 (Cryptosporidium parvum Iowa II) [Search protein sequence]
QFLFSSESVCSGHPDKLCDQISDAILDACLEQDPESFVACETCTKTGFIM
VFGEITTKANVNYERVVRETVKEIGYDSEEKGLDYKTMDVIIKLEQQKNV
EDIGAGDQGMMFGYATNETKELMPLTHVLATSITRELDYIRVKGWLRPDG
KAQVTVEYNCKHGVLIPKRIHTILVSVQHDENIENEEIREFVLENVIKKV
CPSDLMDKETRILINPSGRFTIGGPAADAGLTGRKIIVDTYGGWGAHGGG
AFSGKDATKVDRSGAYMARLVAKSIVFSGLCSRCLVQVSYGIGIARPLSL
YINTFGTAKDGYNDAKLLEIVNKVFDFRPGILIKQLNLKSPIFKKTSSGG
HFGRSEEEFLWEKPIILQ
3D structure
PDB6c07 Structure of a critical metabolic enzyme: S-adenosylmethionine synthetase from Cryptosporidium parvum.
ChainB
Resolution1.85 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H34 D36 K37 E62 E75 K189 F258 D266 A267 R272 K273 K293 K297 D299
Catalytic site (residue number reindexed from 1) H13 D15 K16 E41 E54 K151 F220 D228 A229 R234 K235 K255 K259 D261
Enzyme Commision number 2.5.1.6: methionine adenosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B D266 A267 D228 A229
Gene Ontology
Molecular Function
GO:0004478 methionine adenosyltransferase activity
GO:0005524 ATP binding
GO:0016740 transferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006556 S-adenosylmethionine biosynthetic process
GO:0006730 one-carbon metabolic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6c07, PDBe:6c07, PDBj:6c07
PDBsum6c07
PubMed30950830
UniProtQ5CYE4

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