Structure of PDB 6c01 Chain B

Receptor sequence
>6c01B (length=807) Species: 9606 (Homo sapiens) [Search protein sequence]
SCRKKCFDASCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRL
EASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDCPEGFDLPPVILF
SMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVT
GLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGL
KAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERP
RFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNC
VNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHD
FFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVD
QQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFEN
IEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGF
ANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPR
VLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDC
LRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNL
VPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDE
ITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTN
VESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQL
KTYLPTF
3D structure
PDB6c01 Structural basis for nucleotide recognition by the ectoenzyme CD203c.
ChainB
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.1: phosphodiesterase I.
3.6.1.9: nucleotide diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FUC B V661 D703 Y706 V597 D639 Y642
BS02 ZN B D325 H329 H483 D261 H265 H419
BS03 ZN B D167 T205 D372 H373 D103 T141 D308 H309
BS04 CA B D752 N754 D756 H758 D760 D688 N690 D692 H694 D696
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004081 bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
GO:0004528 phosphodiesterase I activity
GO:0005509 calcium ion binding
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0034432 bis(5'-adenosyl)-pentaphosphatase activity
GO:0036219 GTP diphosphatase activity
GO:0036221 UTP diphosphatase activity
GO:0046872 metal ion binding
GO:0047429 nucleoside triphosphate diphosphatase activity
GO:0047693 ATP diphosphatase activity
GO:0047710 bis(5'-adenosyl)-triphosphatase activity
Biological Process
GO:0002276 basophil activation involved in immune response
GO:0006220 pyrimidine nucleotide metabolic process
GO:0006796 phosphate-containing compound metabolic process
GO:0009143 nucleoside triphosphate catabolic process
GO:0030505 inorganic diphosphate transport
GO:0033007 negative regulation of mast cell activation involved in immune response
GO:0046034 ATP metabolic process
GO:0050728 negative regulation of inflammatory response
GO:0055062 phosphate ion homeostasis
GO:0070667 negative regulation of mast cell proliferation
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0016324 apical plasma membrane
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6c01, PDBe:6c01, PDBj:6c01
PDBsum6c01
PubMed29717535
UniProtO14638|ENPP3_HUMAN Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (Gene Name=ENPP3)

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