Structure of PDB 6bxu Chain B

Receptor sequence

>6bxuB (length=311) Species: 10090 (Mus musculus)

ANDNTPTFPEISYDVYVYTDMSPGDSVIQLTAVDADEGSNGEISYEILVG
GKGDFVINKTTGLVSIAPGVELIVGQTYALTVQASDNAPPAERRHSICTV
YTEVLPPNNQSPPRFPQLMYSLEVSEAMRIGAILLNLQATDREGDPITYA
IENGDPQRVFNLSETTGILSLGKALDRESTDRYILIVTASDGRPDGTSTA
TVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVRATDPDAGINGQ
VHYSLGNFNNLFRITSNGSIYTAVKLNREARDHYELVVVATDGAVHPRHS
TLTLYIKVLDI

3D structure

• PDB: 6bxu Structural determinants of protocadherin-15 mechanics and function in hearing and balance perception.
• Chain: B
• Resolution: 3.79 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	B	Q590 S591 D621 E623 D625 D671	Q110 S111 D141 E143 D145 D191
BS02	CA	B	N690 N692 D722 D724 N728 D772	N210 N212 D242 D244 N248 D292
BS03	CA	B	E606 D656 E658 D691	E126 D176 E178 D211
BS04	CA	B	E606 E658 D688 V689 D691 D724	E126 E178 D208 V209 D211 D244
BS05	CA	B	N482 N484 D514 D516 N520 D566	N2 N4 D34 D36 N40 D86

Gene Ontology

Molecular Function

• GO:0005509 calcium ion binding

Biological Process

• GO:0007155 cell adhesion
• GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:6bxu, PDBe:6bxu, PDBj:6bxu
• PDBsum: 6bxu
• PubMed: 32963095
• UniProt: Q99PJ1|PCD15_MOUSE Protocadherin-15 (Gene Name=Pcdh15)