Structure of PDB 6bxn Chain B

Receptor sequence
>6bxnB (length=316) Species: 1392998 (Candidatus Methanoperedens nitroreducens) [Search protein sequence]
DLERILKTIKDKNCKKVGLQFPEGLKRQAINIAREIEEKTRANVIISGNP
CFGACDIDTILAGSVDILFHFGHAGMGEYENVVFIEARSNIDIIPAVKTA
LNLLKANRIGLITTVQHVHKLEEACKVIKEYGKECVIGKGDPRAIYPGQV
LGCNFTAARVDCEEFIYIGSGIFHPLGVAIATKKRVIAADPFLNQAVEVS
PERFLRKRGGYIAKATGAKIFGIIVSTKSGQYRMKLAQKLKEIADKHGKI
GYIILMDLVTPEQLLAFKADAYVNTACPRITIDDAERFHAPVLTPQEFEI
VLGERRWENMEMDEMI
3D structure
PDB6bxn Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis.
ChainB
Resolution2.079 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.108: 2-(3-amino-3-carboxypropyl)histidine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SF4 B C61 R149 G158 C159 C283 C55 R143 G152 C153 C277
BS02 SAM B F58 H180 K234 Q237 L264 V265 C283 I286 D289 D290 F52 H174 K228 Q231 L258 V259 C277 I280 D283 D284
Gene Ontology
Molecular Function
GO:0016740 transferase activity
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
GO:0090560 2-(3-amino-3-carboxypropyl)histidine synthase activity
Biological Process
GO:0017183 protein histidyl modification to diphthamide

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Molecular Function
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Biological Process
External links
PDB RCSB:6bxn, PDBe:6bxn, PDBj:6bxn
PDBsum6bxn
PubMed29590073
UniProtA0A062UZ78

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