Structure of PDB 6bxl Chain B

Receptor sequence
>6bxlB (length=337) Species: 70601 (Pyrococcus horikoshii OT3) [Search protein sequence]
MLHEIPKSEILKELKRIGAKRVLIQSPEGLRREAEELAGFLEENNIEVFL
HGEINYGACDPADREAKLVGCDALIHLGHSYMKLPLEVPTIFVPAFARVS
VVEALKENIGEIKKLGRKIIVTTTAQHIHQLKEAKEFLESEGFEVSIGRG
DSRISWPGQVLGCNYSVAKVRGEGILFIGSGIFHPLGLAVATRKKVLAID
PYTKAFSWIDPERFIRKRWAQIAKAMDAKKFGVIVSIKKGQLRLAEAKRI
VKLLKKHGREARLIVMNDVNYHKLEGFPFEAYVVVACPRVPLDWRKPVLT
PKEVEILLGLREEYEFDEILGGPRESDEPFGISIHST
3D structure
PDB6bxl Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis.
ChainB
Resolution2.301 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.5.1.108: 2-(3-amino-3-carboxypropyl)histidine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAM B Y56 L161 G162 H184 K238 Q241 D268 V269 C287 R289 V290 Y56 L161 G162 H184 K238 Q241 D268 V269 C287 R289 V290
BS02 SF4 B Y56 C59 G162 C163 C287 R289 Y56 C59 G162 C163 C287 R289
Gene Ontology
Molecular Function
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
GO:0090560 2-(3-amino-3-carboxypropyl)histidine synthase activity
Biological Process
GO:0017183 protein histidyl modification to diphthamide
GO:0050843 S-adenosylmethionine catabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6bxl, PDBe:6bxl, PDBj:6bxl
PDBsum6bxl
PubMed29590073
UniProtO58832|DPH2_PYRHO 2-(3-amino-3-carboxypropyl)histidine synthase (Gene Name=dph2)

[Back to BioLiP]