Structure of PDB 6bwd Chain B

Receptor sequence

>6bwdB (length=771) Species: 10090 (Mus musculus)

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAGAAAKFLTIPRLEELYNTKQGPTNPMLFHLIYK
ITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSLGGNNRRSGRNTSSSTP
QLRKSHKMRHNHFIKTAQPYRPKMDASMEEGKKKRTKDKRFPYPLNELLI
WACLMKRQVMARFLWQHGEESMAKALVACKIYRSMAYEAKQSDTSEELKQ
YSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNSTCLKLAVSSRLR
PFVAHTCTQMLLSDMWMGRLNMWYKVILSILVPPAILMLEYKTKAEMSHI
PQSQDAHQRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVKMEQLPSV
QEWIVIAYIFTYAIEKVREVFMQKIKVWFSDYFNVSDTIAIISFFVGFGL
RFGAKWNYINAYDNHVFVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVM
MIGKMVANMFYIVVIMALVLLSFGVPRKAILYPHEEPSWSLAKDIVFHPY
WMIFGEVYAYEIDVCANDSTLPTICGPGTWLTPFLQAVYLFVQYIIMVNL
LIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLIILSHIGPK
LFLTEEDQKKLHDFEEQCVEMYFDEKDDKFNSGSEERIRVTFERVEQMSI
QIKEVGDRVNYIKRSLQSLDS

3D structure

• PDB: 6bwd Structure of the mammalian TRPM7, a magnesium channel required during embryonic development.
• Chain: B
• Resolution: 3.7 Å

Enzymatic activity

• Enzyme Commision number: 2.7.11.1: non-specific serine/threonine protein kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	Y01	B	L702 M706 T709 F710	L430 M434 T437 F438
BS02	Y01	B	M706 L707 F710 Q723	M434 L435 F438 Q451
BS03	Y01	B	Y597 F694 W695 L702 F817 L818 N821	Y374 F422 W423 L430 F538 L539 N542
BS04	Y01	B	F762 I808 V812	F483 I529 V533
BS05	Y01	B	Y761 S765 I808 F809	Y482 S486 I529 F530
BS06	Y01	B	V848 S851 F852	V569 S572 F573

Gene Ontology

Molecular Function

• GO:0005216 monoatomic ion channel activity

Biological Process

• GO:0006811 monoatomic ion transport
• GO:0051262 protein tetramerization
• GO:0055085 transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:6bwd, PDBe:6bwd, PDBj:6bwd
• PDBsum: 6bwd
• PubMed: 30108148
• UniProt: Q923J1|TRPM7_MOUSE Transient receptor potential cation channel subfamily M member 7 (Gene Name=Trpm7)