Structure of PDB 6buv Chain B

Receptor sequence
>6buvB (length=191) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
RRLGVMGGTFDPIHYGHLVAASEVADLFDLDEVVFVPSGQPWQKGRQVSA
AEHRYLMTVIATASNPRFSVSRVDIDRGGPTYTKDTLADLHALHPDSELY
FTTGADALASIMSWQGWEELFELARFVGVSRPGHITSLLGQLAKDALTLV
EIPALAISSTDCRQRAEQSRPLWYLMPDGVVQYVSKRRLYT
3D structure
PDB6buv Novel Antimycobacterial Compounds Suppress NAD Biogenesis by Targeting a Unique Pocket of NaMN Adenylyltransferase.
ChainB
Resolution1.86 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.18: nicotinate-nucleotide adenylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 E9A B A108 D109 A112 M115 S116 A105 D106 A109 M112 S113 PDBbind-CN: -logKd/Ki=4.74,IC50=18uM
Gene Ontology
Molecular Function
GO:0000309 nicotinamide-nucleotide adenylyltransferase activity
GO:0003824 catalytic activity
GO:0004515 nicotinate-nucleotide adenylyltransferase activity
GO:0005524 ATP binding
GO:0016779 nucleotidyltransferase activity
GO:0070566 adenylyltransferase activity
Biological Process
GO:0009058 biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0009435 NAD biosynthetic process
GO:0019363 pyridine nucleotide biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6buv, PDBe:6buv, PDBj:6buv
PDBsum6buv
PubMed30969758
UniProtP9WJJ5|NADD_MYCTU Probable nicotinate-nucleotide adenylyltransferase (Gene Name=nadD)

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