Structure of PDB 6brh Chain B

Receptor sequence
>6brhB (length=502) Species: 10090 (Mus musculus) [Search protein sequence]
TDLRTWEPEDVCSFLENRGFREKKVLDIFRDNKIAGSFLPFLDEDRLEDL
GVSSLEERKKMIECIQQLSQSRIDLMKVFNDPIHGHIEFHPLLIRIIDTP
QFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVRALAEKQPEL
QISERDILCVQIAGLCHDLGHGPFSHMFDGRFIPRARPEKKWKHEQGSIE
MFEHLVNSNELKLVMKNYGLVPEEDITFIKEQIMGPSLWPYKGRPATKSF
LYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARICEVEYK
VKTYIRKVKHICSREKEVGNLYDMFHTRNCLHRRAYQHKISNLIDIMITD
AFLKADPYVEITGTAGKKFRISTAIDDMEAFTKLTDNIFLEVLHSTDPQL
SEAQSILRNIECRNLYKYLGETQPKREKIRKEEYERLPQEVAKAKPVELK
AEDFIVDVINVDVHFYEQLIRVYCKKKDGKSLDAAGKHFVQWCALRDFTK
PQ
3D structure
PDB6brh The SAM domain of mouse SAMHD1 is critical for its activation and regulation.
ChainB
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DGT B Y187 V188 R494 Y116 V117 R413
BS02 DGT B R75 K148 F150 D169 R177 R4 K77 F79 D98 R106
BS03 MG B H199 H238 D239 D343 H128 H167 D168 D265
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003697 single-stranded DNA binding
GO:0003723 RNA binding
GO:0004540 RNA nuclease activity
GO:0005525 GTP binding
GO:0008270 zinc ion binding
GO:0008832 dGTPase activity
GO:0016787 hydrolase activity
GO:0016793 triphosphoric monoester hydrolase activity
GO:0032567 dGTP binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0106375 deoxynucleoside triphosphate hydrolase activity
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0006203 dGTP catabolic process
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006974 DNA damage response
GO:0009264 deoxyribonucleotide catabolic process
GO:0016446 somatic hypermutation of immunoglobulin genes
GO:0045087 innate immune response
GO:0045088 regulation of innate immune response
GO:0046061 dATP catabolic process
GO:0051289 protein homotetramerization
GO:0051607 defense response to virus
GO:0060339 negative regulation of type I interferon-mediated signaling pathway
GO:0110025 DNA strand resection involved in replication fork processing
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005886 plasma membrane
GO:0035861 site of double-strand break
GO:0097197 tetraspanin-enriched microdomain

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6brh, PDBe:6brh, PDBj:6brh
PDBsum6brh
PubMed29379009
UniProtQ60710|SAMH1_MOUSE Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=Samhd1)

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