Structure of PDB 6bqv Chain B

Receptor sequence
>6bqvB (length=932) Species: 9606 (Homo sapiens) [Search protein sequence]
TGAGRHSNFLRLSDRTDPAAVYSLVTRTWGFRAPNLVVSVLGGSGGPVLQ
TWLQDLLRRGLVRAAQSTGAWIVTGGLHTGIGRHVGVAVRDHQMASTGGT
KVVAMGVAPWGVVRNRDTLINPKGSFPARYRWVQFPLDYNYSAFFLVDDL
GGENRFRLRLESYISQQKTGVGGTGIDIPVLLLLIDGDEKMLTRIENATQ
AQLPCLLVAGSGGAADCLAETLEDTLGEARDRIRRFFPKGDLEVLQAQVE
RIMTRKELLTVYSSEDGSEEFETIVLKALVKACGEASAYLDELRLAVAWN
RVDIAQSELFRGDIQWRSFHLEASLMDALLNDRPEFVRLLISHGLSLGHF
LTPMRLAQLYSAAPSNSLIRNLLDQASVGHVLRMLLGPWSDLLLWALLLN
RAQMAMYFWEMGSNAVSSALGACLLLRVMARLEPDAEEAARRKDLAFKFE
GMGVDLFGECYRSSEVRAARLLLRRCPLWGDATCLQLAMQADARAFFAQD
GVQSLLTQKWWGDMASTTPIWALVLAFFCPPLIYTRLITFRRCLRRWFHF
WGAPVTIFMGNVVSYLLFLLLFSRVLLVDFQPAPPGSLELLLYFWAFTLL
CEELRQGLSGSGGPGPGHASLSQRLRLYLADSWNQCDLVALTCFLLGVGC
RLTPGLYHLGRTVLCIDFMVFTVRLLHIFTVNKQLGPKIVIVSKMMKDVF
FFLFFLGVWLVAYGVATEGLLRPRDSDFPSILRRVFYRPYLQIFGQIPQE
DMDVALMEHSNCSSEPGFWAHPPGAQAGTCVSQYANWLVVLLLVIFLLVA
NILLVNLLIAMFSYTFGKVQGNSDLYWKAQRYRLIREFHSRPALAPPFIV
ISHLRLLLRQLCREHFRVYLSKEAERKLLTWESVHKENFLLARARDKRES
DSERLKRTSQKVDLALKQLGHIREYEQRLKVL
3D structure
PDB6bqv Structure of the human TRPM4 ion channel in a lipid nanodisc.
ChainB
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 CA B E828 Q831 N865 D868 E603 Q606 N634 D637
BS02 Y01 B I690 V694 F783 V788 L791 L795 N913 I520 V524 F558 V563 L566 L570 N682
BS03 Y01 B G938 P960 R964 F967 Y968 G707 P729 R733 F736 Y737
BS04 Y01 B L907 H908 S924 M927 L676 H677 S693 M696
BS05 Y01 B V1021 V1025 V790 V794
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005227 calcium-activated cation channel activity
GO:0005262 calcium channel activity
GO:0005272 sodium channel activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0046872 metal ion binding
GO:0099604 ligand-gated calcium channel activity
Biological Process
GO:0002250 adaptive immune response
GO:0002407 dendritic cell chemotaxis
GO:0002724 regulation of T cell cytokine production
GO:0006811 monoatomic ion transport
GO:0006816 calcium ion transport
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0008284 positive regulation of cell population proliferation
GO:0010460 positive regulation of heart rate
GO:0016925 protein sumoylation
GO:0019722 calcium-mediated signaling
GO:0030502 negative regulation of bone mineralization
GO:0034220 monoatomic ion transmembrane transport
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0045600 positive regulation of fat cell differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045907 positive regulation of vasoconstriction
GO:0051289 protein homotetramerization
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0071318 cellular response to ATP
GO:0086045 membrane depolarization during AV node cell action potential
GO:0086047 membrane depolarization during Purkinje myocyte cell action potential
GO:0086048 membrane depolarization during bundle of His cell action potential
GO:0086091 regulation of heart rate by cardiac conduction
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0098662 inorganic cation transmembrane transport
GO:0098719 sodium ion import across plasma membrane
GO:0098911 regulation of ventricular cardiac muscle cell action potential
GO:1903949 positive regulation of atrial cardiac muscle cell action potential
GO:1904179 positive regulation of adipose tissue development
GO:1904199 positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization
Cellular Component
GO:0005654 nucleoplasm
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0034706 sodium channel complex
GO:0043025 neuronal cell body

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:6bqv, PDBe:6bqv, PDBj:6bqv
PDBsum6bqv
PubMed29217581
UniProtQ8TD43|TRPM4_HUMAN Transient receptor potential cation channel subfamily M member 4 (Gene Name=TRPM4)

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