Structure of PDB 6boo Chain B

Receptor sequence
>6booB (length=435) Species: 451804 (Aspergillus fumigatus A1163) [Search protein sequence]
AEPDLKTALKAVIPAKRELFKQVKERSDEVIGEVKVANVIGGMRGLKSML
WEGSVLDPEEGIRFHGKTIKDCQKELPKGTSGTEMLPEAMFWLLLTGQVP
STNQVRAFSRELAEQSHLPQHILDLIKSFPRSMHPMTQLSIAVAALNTES
KFAKAYEKGLSKADYWEPTFDDSISLLAKIPRVAALVFRPDEVDQVGTQA
LDASQDWSYNFAELLGKGGKENQDFHDLLRLYLALHGDHEGGNVSAHATH
LVGSALSDPFLSYSAGLLGLAGPLHGLAAQEVLRWILAMQDKIGTKFTDD
DVRNYLWDTLKSGRVVPGYGHGVLRKPDPRFQALMDFAATRPDVLANPVF
QLVKKNSEIAPAVLTEHGKTKNPHPNVDAASGVLFYHYGFQQPLYYTVTF
GVSRALGPLVQLIWDRALGLPIERPKSINLLGLKK
3D structure
PDB6boo Comparative studies of Aspergillus fumigatus 2-methylcitrate synthase and human citrate synthase.
ChainB
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S275 H305 H351 R360 D408
Catalytic site (residue number reindexed from 1) S245 H275 H321 R330 D378
Enzyme Commision number 2.3.3.16: citrate synthase (unknown stereospecificity).
2.3.3.5: 2-methylcitrate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OAA B H269 N273 H305 H351 R360 R434 H239 N243 H275 H321 R330 R404
BS02 COA B R74 L304 H305 A308 V345 V346 P347 G348 Y349 G350 H351 K399 T400 K401 N406 R44 L274 H275 A278 V315 V316 P317 G318 Y319 G320 H321 K369 T370 K371 N376
Gene Ontology
Molecular Function
GO:0004108 citrate (Si)-synthase activity
GO:0016740 transferase activity
GO:0036440 citrate synthase activity
GO:0042802 identical protein binding
GO:0046912 acyltransferase activity, acyl groups converted into alkyl on transfer
GO:0050440 2-methylcitrate synthase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006099 tricarboxylic acid cycle
GO:0019629 propionate catabolic process, 2-methylcitrate cycle
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6boo, PDBe:6boo, PDBj:6boo
PDBsum6boo
PubMed31141475
UniProtB0YD89|PRPC_ASPFC 2-methylcitrate synthase, mitochondrial (Gene Name=mcsA)

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