Structure of PDB 6bn5 Chain B

Receptor sequence
>6bn5B (length=448) Species: 9606 (Homo sapiens) [Search protein sequence]
RRWFHPNITGVEAENLLLTRGVDGSFLARPSPGDFTLSVRRNGAVTHIKI
QNTGDYYDLYGGEKFATLAELVQYYMEHELKYPLNCADPERWFHGHLSLL
TEKGKHGSFLVREPGDFVLSVRTGKVTHVMIRCQELKYDVGGGERFDSLT
DLVEHYKKNPMVTVLQLKQPLNTTRINAAEIESRVRELSKQGFWEEFETL
QQQECKLLYSRKEGQRQENKNKNRYKNILPSDHTRVVLHSDYINANIIMP
KSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDE
YALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQTERTVWQYHFRTWPDH
GVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILI
DIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIET
3D structure
PDB6bn5 Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2.
ChainB
Resolution2.22 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DZJ B R111 E250 T253 L254 Q257 P491 K492 M496 R91 E196 T199 L200 Q203 P415 K416 M420
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6bn5, PDBe:6bn5, PDBj:6bn5
PDBsum6bn5
PubMed29089257
UniProtQ06124|PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11 (Gene Name=PTPN11)

[Back to BioLiP]