Structure of PDB 6bmu Chain B

Receptor sequence
>6bmuB (length=474) Species: 9606 (Homo sapiens) [Search protein sequence]
RRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTH
IKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLDVIELKYPLNCADPT
SERWFHGHLSGAEKLLTEKGKHGSFLVREPGDFVLSVRTSKVTHVMIRCQ
ELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAE
IESRVRELSKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILP
FDHTRVVLHVSDYINANIIMPPKKSYIATQGCLQNTVNDFWRMVFQENSR
VIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLREL
KLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMD
AGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQR
SGMVQTEAQYRFIYMAVQHYIETL
3D structure
PDB6bmu Dual Allosteric Inhibition of SHP2 Phosphatase.
ChainB
Resolution2.12 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D425 C459 R465 T466 Q506
Catalytic site (residue number reindexed from 1) D374 C408 R414 T415 Q455
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5OD B E110 R111 F113 T219 E249 E250 T253 L254 Q257 P491 K492 Q495 E102 R103 F105 T194 E215 E216 T219 L220 Q223 P440 K441 Q444 BindingDB: IC50=70.0nM
BS02 DZV B Q79 Y80 E83 H84 L262 Y263 S264 R265 Q269 N281 Q76 Y77 E80 H81 L228 Y229 S230 R231 Q235 N247
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6bmu, PDBe:6bmu, PDBj:6bmu
PDBsum6bmu
PubMed29304282
UniProtQ06124|PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11 (Gene Name=PTPN11)

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